The carrier operates a total of 137 domestic airport-pairs involving 58 Chinese airports, plus nine international routes. In 2010, the airline carried 16.5 million passengers, up 9% on the previous year.
In July 2015, Shenzhen Airlines Flight 9648 was on approach to Guangzhou Airport when a passenger set two seats and the forward door on fire. Other passengers were able to extinguish the fire and save the aircraft. An emergency evacuation was carried out at Guangzhou, injuring 2 passengers slightly. The airline and 2 passengers were rewarded for saving the 102 lives on board.
On 26 June 2016, Shenzhen Airlines Flight ZH9041 from Quanzhou (JJN) to Hong Kong (HKG) experienced a "near crash" into a mountain on Lantau Island, south of Hong Kong International Airport when the A320 aircraft was going around. The flight flew into the no-fly-zone over the island at an altitude lower than Lantau Peak. Shenzhen Airlines suspended a pilot over the incident.